ABSTRACT
Abstract Introduction Malignant mesonephric tumors are uncommon in the female genital tract, and they are usually located where embryonic remnants of Wolffian ducts are detected, such as the uterine cervix. The information about these tumors, their treatment protocol, and prognosis are scarce. Case report A 60-year-old woman with postmenopausal vaginal bleeding was initially diagnosed with endometrial carcinoma. After suspicion co-testing, the patient underwent a loop electrosurgical excision of the cervix and was eventually diagnosed with mesonephric adenocarcinoma. She was subjected to a radical hysterectomy, which revealed International Federation of Gynecology and Obstetrics (FIGO) IB1 stage, and adjuvant radiotherapy. The follow-up showed no evidence of recurrence after 60 months. Conclusion We present the case of a woman with cervical mesonephric adenocarcinoma. When compared with the literature, this case had the longest clinical follow-up without evidence of recurrence, which reinforces the concept that these tumors are associated with a favorable prognosis if managed according to the guidelines defined for the treatment of patients with cervical adenocarcinomas. Though a rare entity, it should be kept in mind as a differential diagnosis for other cervical cancers.
Subject(s)
Humans , Female , Uterine Cervical Neoplasms/diagnosis , Mesonephroma/diagnosis , Uterine Cervical Neoplasms/surgery , Uterine Cervical Neoplasms/embryology , Uterine Cervical Neoplasms/pathology , Radiotherapy, Adjuvant , Diagnosis, Differential , Hysterectomy , Mesonephroma/surgery , Mesonephroma/embryology , Mesonephroma/pathology , Middle Aged , Neoplasm InvasivenessABSTRACT
Os autores estudaram sete casos de disgerminoma e tres de tumor do seio endodermico do ovario, no intuito de avaliar a utilidade da imunohistoquimica, empregando anticorpos anti-citoceratina, alfa-fetoproteina e alfa-1-antitripsina no diagnostico destes tumores. Os 10 tumores expressaram alfa-1-antitripsina. Nenhum disgerminoma expressou citoceratina enquanto todos os tumores do seio endodermico mostraram reacoes positivas. Os tres tumores do seio endodermico e um disgerminoma expressaram alfa-fetoproteina. Apos investigacao detalhada, este caso foi classificado como um tumor misto de celulas germinativas, tambem por corresponder a um mau prognostico e curta sobrevida, nao muito caracteristico de disgerminomas puros. Este estudo indica que a imunohistoquimica pode ser util no diagnostico destes tipos de tumor, principalmente quando ha areas suspeitas que podem levar a um diagnostico de um tumor misto de celulas germinativas.
Subject(s)
Humans , Female , Dysgerminoma/diagnosis , Immunohistochemistry , Mesonephroma/diagnosis , Ovarian Neoplasms/pathology , Antibodies, Anti-Idiotypic/immunology , Dysgerminoma/analysis , Mesonephroma/analysisABSTRACT
El tumor del Seno Endodermal (TSE) es una neoplasia de las células germinales, de baja presentación en la población general y extraordinariamente rara en el compartimiento mediastinal. En el presente informe se hace referencia de un paciente de 20 años de edad que presentó TSE del mediastino anterior de grandes dimensiones, localmente avanzado y con comportamiento muy agresivo. El diagnóstico se estableció mediante biopsia intratorácica percutánea por aspiración y el paciente recibió quimioterapia combinada con plantino y eptopósido, falleciendo antes de completar el primer curso de tratamiento
Subject(s)
Humans , Adult , Male , Mesonephroma/diagnosis , Mesonephroma/drug therapy , Mesonephroma/radiotherapy , Germ Cells/anatomy & histology , Germ Cells/pathologyABSTRACT
An endodermal sinus tumour of the anterior mediatinum is described in a19-year-old man. This very rare condition is reported for the first time in the Caribbean literature